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The metallo-beta-lactamase protein fold is a protein domain contained in class B beta-lactamases and a number of other proteins .〔 These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in ''Neisseria gonorrhoeae'' and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor. Metallo-beta-lactamases are important enzymes because they are involved in the breakdown of antibiotics by antibiotic-resistant bacteria. It is unclear whether metallo-beta-lactamase activity evolved once or twice within the superfamily; if twice, this would suggest structural exaptation. ==See also== * New Delhi metallo-beta-lactamase 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Metallo-beta-lactamase protein fold」の詳細全文を読む スポンサード リンク
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